Format

Send to

Choose Destination
See comment in PubMed Commons below
Parasitol Today. 1989 Jul;5(7):215-8.

Neurobiology of sleeping sickness.

Author information

1
Department of Biological Sciences, University of Salford, Salford M5 4WT, UK.

Abstract

The advanced stages of sleeping sickness are correlated with a spread of trypanosomes into the central nervous system (CNS), producing a disseminated encephalitis. Inflammatory reactions extend along the blood vessels causing perivascular cuffing, which consists of in filtrations and proliferations of lymphocytes and also increased numbers of astrocytes and microglia. Progress in our understanding of the functions of astrocytes suggests that they are efficient antigen-presenting cells, initiating and regulating the intracerebral inflammatory response and limiting parasite spread to the perivascular spaces.

PMID:
15463220
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center