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Parasitol Today. 1989 Oct;5(10):327-9.

Cardiac parasympathetic abnormalities: Cause or consequence of chagas heart disease?

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Diego F. Davila, R. Osman Rossell and Jose Donis are at the Centro Cardiovascular y Departamento de Biologia, Universidad de Los Andes, Apartodo Postal 590, Merida 5101, Venezuela.


The mechanisms by which Trypanosoma cruzi causes cardiomyopathy are unknown but are the subject o f several hypotheses. In this paper, Diego Davila, Osman Rossell and Jose Donis discuss the aetiology of cardiac failure in Chagas disease and suggest that parasympathetic abnormalities are a consequence of, rather than the cause of, the progressive cardiac enlargement seen in these patients.

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