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Genome Biol. 2004;5(10):242. Epub 2004 Sep 28.

Hotspots of homologous recombination in the human genome: not all homologous sequences are equal.

Author information

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. jlupski@sanger.ac.uk

Abstract

Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.

PMID:
15461806
PMCID:
PMC545587
DOI:
10.1186/gb-2004-5-10-242
[Indexed for MEDLINE]
Free PMC Article

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