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Epilepsia. 2004 Oct;45(10):1184-8.

Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.

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1
Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Abstract

PURPOSE:

The purpose of this study was to determine whether N-palmitoylethanolamide (PEA), a putative endocannabinoid, would be effective against kindled amygdaloid seizures. For a comparison with earlier work, we also tested the effectiveness of PEA against pentylenetetrazol (PTZ)-induced convulsions.

METHODS:

Kindling electrodes were implanted bilaterally in the amygdala in 32 Long-Evans rats. After the kindling of generalized (stage 5) seizures, the effects of PEA administration [i.p.; 1, 10, 100 mg/kg in dimethylsulfoxide (DMSO)] were evaluated for anticonvulsant activity. PEA (40 mg/kg, i.p. in DMSO) also was tested for anticonvulsant activity against PTZ-induced convulsions (75 mg/kg, i.p.).

RESULTS:

After i.p. administration of PEA, kindled rats displayed an increased latency to clonus at the 1-mg/kg dose. No other dose-dependent effects were noted. When tested against PTZ-induced convulsions, PEA protected against tonic convulsions and prolonged the latency between convulsive episodes.

CONCLUSIONS:

PEA produces antiepileptic effects, but does not completely suppress seizures. The mechanism of action of PEA remains to be defined.

[Indexed for MEDLINE]
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