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Allergy. 2004 Nov;59(11):1219-23.

Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine?

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Inmunología, Dpto. Bioquímica Clínica, Facultad de Ciencias Químicas--Universidad Nacional de Córdoba, Argentina.


Chemokines are a superfamily of small cytokines with activities ranging from leukocyte traffick to hematopoiesis, angiogenesis, and tissue organogenesis. Secondary lymphoid-organ chemokine (SLC/CCL21) was originally reported as a chemokine constitutively expressed by stromal cells and high endothelial venules in secondary lymphoid tissues and endothelium of afferent lymphatics, directing CCR7+ cells. More recently, others and we have demonstrated that SLC/CCL21 is up-regulated in different skin inflammatory conditions. Thereafter, this molecule is much more than a constitutive chemokine, which could play a role in effector and regulatory immune functions.

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