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Arch Pharm Res. 2004 Aug;27(8):825-8.

Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription.

Author information

1
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.

Abstract

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).

PMID:
15460442
[Indexed for MEDLINE]

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