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Antenatal diagnosis of intrauterine infection with coxsackievirus B3 associated with live birth.

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada. aouellet@ottawahospital.on.ca

Abstract

BACKGROUND:

Prior reported cases of stillbirth and neonates infected with enteroviruses suggest transplacental infection. We present a case of fetal infection with coxsackievirus B3, diagnosed antenatally and resulting in live birth.

CASE:

A pregnant woman presented at 26 weeks with fetal tachycardia and non-immune hydrops fetalis. Coxsackievirus B3 was cultured from amniotic fluid. Maternal antibody to coxsackievirus B3 was positive at 1:512. At 32 weeks, the fetus deteriorated and was delivered. Cord blood antibody to coxsackievirus B3 was positive at a higher titer. Following neonatal death, brain and placental tissues were positive for enterovirus ribonucleic acid by polymerase chain reaction.

CONCLUSION:

Intrauterine infection by enteroviruses should be considered in the differential diagnosis of non-immune hydrops fetalis. Antenatal diagnosis of coxsackievirus B3 infection is associated with poor outcome.

PMID:
15460192
PMCID:
PMC1784589
DOI:
10.1080/1064744042000210357
[Indexed for MEDLINE]
Free PMC Article
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