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Nat Rev Immunol. 2004 Oct;4(10):762-74.

IDO expression by dendritic cells: tolerance and tryptophan catabolism.

Author information

1
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA. amellor@mail.mcg.edu

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.

PMID:
15459668
DOI:
10.1038/nri1457
[Indexed for MEDLINE]

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