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Nat Rev Mol Cell Biol. 2004 Oct;5(10):836-47.

Liver regeneration: from myth to mechanism.

Author information

1
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA. rebecca.taub@roche.com

Abstract

The unusual regenerative properties of the liver are a logical adaptation by organisms, as the liver is the main detoxifying organ of the body and is likely to be injured by ingested toxins. The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches. So what is known about this process at present and which questions remain?

PMID:
15459664
DOI:
10.1038/nrm1489
[Indexed for MEDLINE]
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