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Nat Rev Mol Cell Biol. 2004 Oct;5(10):805-15.

Connecting proliferation and apoptosis in development and disease.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, 169117, Heidelberg, Germany. hipfner@embl.de

Abstract

Cells grow and divide rapidly during embryonic and postnatal development. Net tissue growth reflects the balance between the addition of new cells and the elimination of existing cells by programmed cell death. Cells compete for growth and survival factors to ensure an appropriate balance between the addition and elimination of cells. Elaborate mechanisms ensure that cells do not evade these constraints, and thereby prevent uncontrolled proliferation.

PMID:
15459661
DOI:
10.1038/nrm1491
[Indexed for MEDLINE]

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