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Nat Rev Mol Cell Biol. 2004 Oct;5(10):792-804.

Checking on DNA damage in S phase.

Author information

1
Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. bartek@biobase.dk

Abstract

The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.

PMID:
15459660
DOI:
10.1038/nrm1493
[Indexed for MEDLINE]
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