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Nat Rev Mol Cell Biol. 2004 Oct;5(10):781-91.

Pathways of chaperone-mediated protein folding in the cytosol.

Author information

1
Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.

Abstract

Cells are faced with the task of folding thousands of different polypeptides into a wide range of conformations. For many proteins, the folding process requires the action of molecular chaperones. In the cytosol of prokaryotic and eukaryotic cells, molecular chaperones of different structural classes form a network of pathways that can handle substrate polypeptides from the point of initial synthesis on ribosomes to the final stages of folding.

PMID:
15459659
DOI:
10.1038/nrm1492
[Indexed for MEDLINE]

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