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J Microbiol. 2004 Sep;42(3):223-7.

Isolation and characterization of alpha-glucosidase inhibitor from the fungus Ganoderma lucidum.

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Department of Biological Engineering, Seokyeong University, Seoul 136-704, Korea.


An alpha-glucosidase inhibitor, SKG-3, was isolated from the fruiting bodies of Ganoderma lucidum and its physico-chemical properties were characterized. It was a highly specific and effective reversible inhibitor of alpha-glucosidase. It showed very potent inhibitory activity against alpha-glucosidase with an IC50 value of 4.6 micro g/ml, but no activity for any other glycosidases tested. Enzyme activity could be recovered upon dialysis, thus providing evidence for the reversibility of the inhibition. A Lineweaver-Burk plot indicated that the SKG-3 inhibition of alpha-glucosidase was competitive.

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