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Nature. 1992 Mar 12;356(6365):126-31.

Crystal structure of four-stranded Oxytricha telomeric DNA.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
2
MIT, Cambridge

Abstract

The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.

PMID:
1545863
DOI:
10.1038/356126a0
[Indexed for MEDLINE]

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