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Anticancer Drugs. 2004 Oct;15(9):825-33.

Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents.

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1
BioMedES, Aberdeen, UK. wheatley@abdn.ac.uk

Abstract

Interest has recently been revived in enzymes that degrade essential amino acids. Arginine-catabolizing enzymes now predominate and are discussed in this review. Apart from reducing tumor load through cell death occurring as a result of deprivation alone, these catabolic enzymes conveniently leave the remaining malignant cells vulnerable to other therapeutic modalities through combinatorial treatments with cycle-dependent drugs, the timing of additional treatment after deprivation being crucial.

[Indexed for MEDLINE]

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