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Opt Lett. 2004 Sep 1;29(17):1974-6.

Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions.

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  • 1Research Center COM, Technical University of Denmark, DK-2800 Kgs Lyngby, Denmark.


We demonstrate highly efficient evanescent-wave detection of fluorophore-labeled biomolecules in aqueous solutions positioned in the air holes of the microstructured part of a photonic crystal fiber. The air-suspended silica structures located between three neighboring air holes in the cladding crystal guide light with a large fraction of the optical field penetrating into the sample even at wavelengths in the visible range. An effective interaction length of several centimeters is obtained when a sample volume of less than 1 microL is used.

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