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Mech Dev. 2004 Nov;121(11):1335-51.

Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis.

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Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.


Myosin VI is an unconventional Myosin that has been implicated in vesicle transport and membrane trafficking. We isolated lethal mutants of Myosin VI, which lack protein once maternal supplies have been utilised during embryogenesis. Dorsal closure, where there is a ring of Myosin VI at the edge of the migrating epithelial sheet, is often abnormal. The sheet of migrating cells is irregular, rather than a smooth epithelium and cells begin to detach. Some embryos hatch into larvae, containing detached cells loose in the haemolymph. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.

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