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Bioorg Med Chem Lett. 2004 Nov 1;14(21):5343-6.

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Author information

1
CREST Research Project, Japan Science and Technology Agency, Saitama 332-0012, Japan.

Abstract

Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.

PMID:
15454224
DOI:
10.1016/j.bmcl.2004.08.016
[Indexed for MEDLINE]

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