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Cell. 2004 Oct 1;119(1):9-18.

Sculpting the proteome with AAA(+) proteases and disassembly machines.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA(+) ATPase family-function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Exciting progress has been made in understanding how AAA(+) machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.

PMID:
15454077
PMCID:
PMC2717008
DOI:
10.1016/j.cell.2004.09.020
[Indexed for MEDLINE]
Free PMC Article

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