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Zhonghua Kou Qiang Yi Xue Za Zhi. 2004 Jul;39(4):291-3.

[Epstein-Barr virus infection in benign lymphoepithelial lesions with malignant transformation of salivary glands].

[Article in Chinese]

Author information

1
Department of Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China. lanyanw@yahoo.com.cn

Abstract

OBJECTIVE:

To examine the role of Epstein-Barr virus (EBV) infection in benign lymphoepithelial lesions with malignant transformation of salivary glands.

METHODS:

2 cases benign lymphoepithelial lesions with focal malignant transformation (BLEL-FMT), 14 cases of malignant lymphoepithelial lesion (MLEL) and 4 cases of benign lymphoepithelial lesion (BLEL) of salivary glands, 4 cases of nonspecific chronic sialadenitis were examined. Sections were cut from the paraffin blocks and performed in situ hybridization (ISH) for EBV encoded small RNA-1 (EBER-1) using 30-base synthesized oligonucleotide probe and polymerase chain reaction (PCR) for BamHI-W regein of EBV DNA (123 bp).

RESULTS:

In ISH, strong signals for EBER-1 were obtained in most of epithelial cell nuclei in examined specimens of BLEL-FMT, no matter in benign or malignant areas and in all specimens of MLEL (14/14), PCR demonstrated a DNA fragment of 123 kbp in 2 cases of BLEL-FMT and 12 cases of MLEL (12/14). In contrast, there were no significant ISH/PCR signals in examined BLEL and nonspecific chronic sialadenitis.

CONCLUSIONS:

A few cases of MLEL may arise from BLEL and EBV may plays an important role in the pathogenesis of BLEL-FMT of salivary glands.

PMID:
15454012
[Indexed for MEDLINE]

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