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J Am Chem Soc. 2004 Oct 6;126(39):12270-1.

Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes.

Author information

1
Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

Abstract

Electrochemical DNA detection systems are an attractive approach to the development of multiplexed, high-throughput DNA analysis systems for clinical and research applications. We have engineered a new class of nanoelectrode ensembles (NEEs) that constitute a useful platform for biomolecular electrochemical sensing. High-sensitivity DNA detection was achieved at oligonucleotide-functionalized NEEs using a label-free electrocatalytic assay. Attomole levels of DNA were detected using the NEEs, validating the promise of nanoarchitectures for ultrasensitive biosensing.

PMID:
15453752
DOI:
10.1021/ja0458221
[Indexed for MEDLINE]

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