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Neurology. 2004 Sep 28;63(6):1081-3.

Plasma exchange for severe optic neuritis: treatment of 10 patients.

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Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Julius-Maximilians University, Josef-Schneider Str. 11, 97080 W├╝rzburg, Germany.


The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids. PE was associated with an improvement of visual acuity according to the study criteria in 7 of 10 patients. On follow-up, three of these patients continued to improve, two remained stable, and two had worsened again. PE may be beneficial as an escalating treatment in a subset of patients with severe ON. A controlled trial is warranted.

[Indexed for MEDLINE]

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