Macaque model for severe acute respiratory syndrome

Thomas Rowe; Guangping Gao; Robert J Hogan; Ronald G Crystal; Thomas G Voss; Rebecca L Grant; Peter Bell; Gary P Kobinger; Nelson A Wivel; James M Wilson

doi:10.1128/JVI.78.20.11401-11404.2004

Macaque model for severe acute respiratory syndrome

J Virol. 2004 Oct;78(20):11401-4. doi: 10.1128/JVI.78.20.11401-11404.2004.

Authors

Thomas Rowe¹, Guangping Gao, Robert J Hogan, Ronald G Crystal, Thomas G Voss, Rebecca L Grant, Peter Bell, Gary P Kobinger, Nelson A Wivel, James M Wilson

Affiliation

¹ 204 Wistar, 3601 Spruce St., Philadelphia, PA 19104. wilsonjm@mail.med.upenn.edu

Abstract

Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Humans
Lung / pathology
Lung / virology
Macaca
Severe Acute Respiratory Syndrome / pathology
Severe Acute Respiratory Syndrome / physiopathology*
Severe Acute Respiratory Syndrome / virology
Severe acute respiratory syndrome-related coronavirus / isolation & purification
Severe acute respiratory syndrome-related coronavirus / pathogenicity*