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J Cell Biol. 2004 Sep 27;166(7):949-55.

The mechanism of spindle assembly: functions of Ran and its target TPX2.

Author information

1
Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany. o.gruss@zmbh.uni-heidelberg.de

Abstract

Recent work has provided new insights into the mechanism of spindle assembly. Growing evidence supports a model in which the small GTPase Ran plays a central role in this process. Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle assembly. We review the current knowledge on the Ran downstream targets for spindle assembly and we focus on the multiple roles of TPX2, one of the targets of RanGTP during cell division.

PMID:
15452138
PMCID:
PMC2172015
DOI:
10.1083/jcb.200312112
[Indexed for MEDLINE]
Free PMC Article

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