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Antiviral Res. 2004 Oct;64(1):1-15.

Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection.

Author information

1
INSERM Unit 271, Insitut Universitaire de France, 151 Cours Albert Thomas, 69003 Lyon, France. zoulim@lyon.inserm.fr

Abstract

Chronic Hepatitis B virus (HBV) infections remain a major problem public health problem worldwide, as well as a therapeutic challenge for clinicians. This review focuses on the main viral and host determinants involved in HBV persistence in infected cells. The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches.

PMID:
15451174
DOI:
10.1016/j.antiviral.2004.07.003
[Indexed for MEDLINE]

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