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Respir Physiol Neurobiol. 2004 Sep 15;142(2-3):95-113.

Parathyroid hormone-related protein and lung biology.

Author information

1
Anesthesiology Service, VA San Diego Healthcare System, University of California, 3350 La Jolla Village Dr., Mailcode 125, San Diego, CA 92161-5085, USA. rhhastings@ucsd.edu

Abstract

Parathyroid hormone-related protein (PTHrP) is expressed in normal and malignant lung and has roles in development, homeostasis, and pathophysiology of injury and cancer. Its effects in developing lung include regulation of branching morphogenesis and type II cell maturation. In adult lung, PTHrP stimulates disaturated phosphatidylcholine secretion, inhibits type II cell growth, and sensitizes them to apoptosis. In lung cancer, PTHrP may play a role in carcinoma progression, or metastasis. The protein could be a useful marker for assessing lung maturity or type II cell function, predicting risk of injury, and detecting lung cancer. PTHrP-based therapies could also prove useful in lung injury and lung cancer.

PMID:
15450473
DOI:
10.1016/j.resp.2004.05.007
[Indexed for MEDLINE]

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