Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2004 Sep 30;44(1):23-30.

Spike timing-dependent plasticity of neural circuits.

Author information

1
Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA. ydan@berkeley.edu

Abstract

Recent findings of spike timing-dependent plasticity (STDP) have stimulated much interest among experimentalists and theorists. Beyond the traditional correlation-based Hebbian plasticity, STDP opens up new avenues for understanding information coding and circuit plasticity that depend on the precise timing of neuronal spikes. Here we summarize experimental characterization of STDP at various synapses, the underlying cellular mechanisms, and the associated changes in neuronal excitability and dendritic integration. We also describe STDP in the context of complex spike patterns and its dependence on the dendritic location of the synapse. Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule.

PMID:
15450157
DOI:
10.1016/j.neuron.2004.09.007
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center