Prevention of recurrent Reis-Bücklers dystrophy following excimer laser phototherapeutic keratectomy with topical mitomycin C

Cornea. 2004 Oct;23(7):732-5. doi: 10.1097/01.ico.0000127476.37175.6d.

Abstract

Purpose: To report a case of excimer laser phototherapeutic keratectomy (PTK) for Reis-Bücklers dystrophy with a single intraoperative application of adjunctive topical 0.02% mitomycin C (MMC).

Methods: Interventional case report and review of the literature.

Results: A 73-year-old woman with visually significant Reis-Bücklers dystrophy underwent PTK of her right eye with 0.02% adjunctive MMC for visual rehabilitation. Before treatment, best corrected visual acuity (BCVA) was 20/400. The left eye had previously undergone PTK on 2 occasions without MMC, and the dystrophy had recurred following each treatment. One year after the procedure, her MMC-treated cornea remains clear with no recurrence of Reis-Bücklers dystrophy.

Conclusions: The use of topical MMC in conjunction with PTK may be a safe and effective treatment of Reis-Bücklers dystrophy and may be helpful in preventing recurrence of the disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Topical
  • Aged
  • Alkylating Agents / administration & dosage*
  • Alkylating Agents / therapeutic use
  • Chemotherapy, Adjuvant
  • Corneal Dystrophies, Hereditary / pathology
  • Corneal Dystrophies, Hereditary / surgery*
  • Female
  • Humans
  • Intraoperative Care
  • Lasers, Excimer
  • Mitomycin / administration & dosage*
  • Mitomycin / therapeutic use
  • Photorefractive Keratectomy*
  • Secondary Prevention

Substances

  • Alkylating Agents
  • Mitomycin