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Bioreductive mechanisms.

Author information

1
CRC Department of Medical Oncology, University of Glasgow, Bearsden, UK.

Abstract

The design, development, and application of bioreductive antitumor agents in a rational way requires a detailed understanding of the mechanisms involved in their action. In addition to measuring and manipulating tumor hypoxia, we need to elucidate the particulars of the activation versus bioprotection pathways and the nature and properties of the participating enzymes. These areas are reviewed with particular reference to the development of novel quinone, nitro and N-oxide bioreductives.

PMID:
1544830
DOI:
10.1016/0360-3016(92)90493-2
[Indexed for MEDLINE]

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