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FEBS Lett. 1992 Mar 24;299(1):57-9.

Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum.

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1
Department of Pharmacology, University of Miami School of Medicine, FL 33101.

Abstract

The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.

PMID:
1544475
DOI:
10.1016/0014-5793(92)80100-u
[Indexed for MEDLINE]
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