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FEBS Lett. 1992 Feb 17;298(1):29-32.

Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum.

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1
Department of Biochemistry, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.

Abstract

Human tissue inhibitor of metalloproteinases-1 (TIMP-1), but not TIMP-2, has potent growth-promoting activity for a wide range of human and bovine cells. TIMP-1 seems to be a new cell-growth factor in serum and to stimulate the cells independently of its inhibitory activity.

PMID:
1544418
[Indexed for MEDLINE]
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