Format

Send to

Choose Destination
Clin Exp Immunol. 1992 Mar;87(3):435-7.

Regulation of IL-2 production by mononuclear cells from rheumatoid arthritis synovial fluids.

Author information

1
University of Texas Health Science Center, San Antonio 78284-7874.

Abstract

Products of polyamine oxidation down-regulate IL-2 production by peripheral blood T cells. We show here that the production of IL-2 by rheumatoid arthritis synovial fluid mononuclear cells is inversely correlated with the concentrations of polyamines in these cells. In addition, the inhibition of polyamine biosynthesis or oxidation in cultures of these cells enhances their ability to produce IL-2. Our findings suggest that polyamine oxidation plays an important role in the suppression of T cell function characteristic of rheumatoid arthritis synovial fluids.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center