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Br J Psychiatry. 1992 Jan;160:7-11.

A critical appraisal of X-linked bipolar illness. Evidence for the assumed mode of inheritance is lacking.

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Klinik für Kinder- und Jugendpsychiatrie, Universität Marburg, Germany.


The major assumption underlying all X-linkage studies of bipolar disorder has been that a subgroup of manic-depressive illness follows an X-linked dominant mode of inheritance. An evaluation of the segregation patterns in the pedigrees that have been analysed for X-linkage over the past 20 years does not support this assumption, because the formal genetic criteria for an X-linked dominant mode of inheritance are virtually absent. Not a single pedigree has been ascertained in which the segregation pattern is suggestive of the assumed mode of inheritance. This is mainly because segregation ratios characteristic for X-linked dominant inheritance cannot be observed among the offspring of affected males.

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