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J Med Chem. 1992 Feb 21;35(4):676-83.

4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists.

Author information

1
Laboratory of Chemistry, Research Center, J. Uriach & Cía.S.A., Barcelona, Spain.

Abstract

A series of 4-substituted 2-alkoxytetrahydrofuran derivatives featuring an acetal group were prepared and evaluated for PAF antagonist activity in the PAF-induced in vitro platelet-aggregation and in vivo hypotension tests. Compound 2-[[N-acetyl-N-[[[2-(octadecyloxy)tetrahydrofuran-4- yl]methoxy]carbonyl]amino]methyl]-1-ethylpyridinium chloride (4e, UR-11353) was selected for further development on the basis of its high activity and long-lasting action. The compound maintained a significant activity even 24 h after administration of a single dose of 1 mg/kg iv in the PAF-induced mortality test in mice and 10 h after administration of the same dose in the PAF-induced hypotension test in rats. Comparison with previously reported carba analogues suggests that the presence of the acetal group is the structural characteristic that confers its long-lasting activity.

PMID:
1542094
DOI:
10.1021/jm00082a007
[Indexed for MEDLINE]

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