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Biochim Biophys Acta. 1992 Mar 5;1116(1):11-6.

Antioxidative activity of synthetic melanins. Cardiolipin liposome model.

Author information

1
Department of Biochemistry and Biophysics, Silesian Medical Academy, Sosnowiec, Poland.

Abstract

The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe(2+)-ascorbic acid-induced peroxidation of cardiolipin liposomes has been studied. All these melanins are able to inhibit both the ultraviolet- and the Fe(2+)-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin less than melanin synthesized from dopamine in the presence of Cu(2+) less than DOPA--melanin less than melanin synthesized from adrenaline in the presence of Cu(2+) approximately equal to adrenolutin-melanin, and correlates with their ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.

PMID:
1540619
DOI:
10.1016/0304-4165(92)90121-a
[Indexed for MEDLINE]

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