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Br Heart J. 1992 Feb;67(2):122-8.

Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial.

Author information

1
Glenfield General Hospital, Leicester.

Abstract

OBJECTIVE:

To determine whether concomitant treatment with intravenous heparin affects coronary patency and outcome in patients treated with alteplase thrombolysis for acute myocardial infarction.

DESIGN:

Double blind randomised trial.

TREATMENT REGIMENS:

Alteplase 100 mg (not weight adjusted) plus aspirin (250 mg intravenously followed by 75-125 mg on alternate days) plus heparin (5000 units intravenously followed by 1000 units hourly without dose adjustment) was compared with alteplase plus aspirin plus placebo for heparin.

SETTING:

19 cardiac centres in six European countries.

SUBJECTS:

652 patients aged 21-70 years with clinical and electrocardiographic features of infarcting myocardium in whom thrombolytic therapy could be started within six hours of the onset of major symptoms.

MAIN OUTCOME MEASURE:

Angiographic coronary patency 48-120 hours after randomisation.

RESULTS:

Coronary patency (TIMI grades 2 or 3) was 83.4% in the heparin group and 74.7% in the group given placebo for heparin. The relative risk of an occluded vessel in the heparin treated group was 0.66 (95% confidence interval 0.47 to 0.93). Mortality was the same in both groups. There were non-significant trends towards a smaller enzymatic infarct size and a higher incidence of bleeding complications in the group treated with heparin.

CONCLUSIONS:

Concomitant intravenous heparin improves coronary patency in patients with alteplase. Whether this can be translated into improved clinical benefit needs to be to be tested in a larger trial.

PMID:
1540431
PMCID:
PMC1024740
DOI:
10.1136/hrt.67.2.122
[Indexed for MEDLINE]
Free PMC Article

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