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Folinic acid therapy fails to improve early Parkinson's disease: a two week placebo controlled clinical trial.

Author information

1
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilian-University, Munich, Federal Republic of Germany.

Abstract

Folinic acid (15 mg bid, po) was administered in a two week, double-blind, placebocontrolled, cross over clinical trial in 5 patients with Parkinson's disease (Hoehn and Yahr stage I or II). 4 patients had not been on L-dopa treatment prior to entering this trial and one patient was on a small dose of L-dopa. No significant improvement could be detected in this pilot study by clinical evaluation and motor performance assessed by a computer assisted motor performance test.

PMID:
1540304
[Indexed for MEDLINE]

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