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Biochem Biophys Res Commun. 1992 Feb 14;182(3):1326-32.

Cloning of the Drosophila prospero gene and its expression in ganglion mother cells.

Author information

1
Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan.

Abstract

The Drosophila central nervous system comprises an enormous diversity of neurons that are originated from neuronal stem cells, neuroblasts. They generate a specific series of ganglion mother cells, each of which is once cleaved into a pair of neurons. Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons. Here we report that pros encodes a nuclear protein containing a homeodomain-like sequence. In neuronal lineages of the central nervous system, pros protein is specifically detected in ganglion mother cells, although their parental neuroblasts have begun expressing a significant level of pros transcripts, suggesting a post-transcriptional control of pros expression. Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function.

PMID:
1540176
DOI:
10.1016/0006-291x(92)91878-t
[Indexed for MEDLINE]

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