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Pediatr Blood Cancer. 2004 Nov;43(6):659-67.

Health status of young children during therapy for advanced neuroblastoma.

Author information

1
Department of Pediatrics, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.

Abstract

BACKGROUND:

The purpose of this study was to describe the health status experienced by young children during various phases of therapy for advanced neuroblastoma.

METHODS:

Nineteen patients aged 2.00-4.99 years at the time of diagnosis of neuroblastoma (stages 3 or 4) who received active therapy between 1996 and 2000 were enrolled on the study. Their parents provided proxy assessments of their health status at a maximum of 10 assessment points during therapy using the Comprehensive Health Status Classification System for Pre-school Children (CHSCS-PS), which assesses level of function on 10 separate health domains.

RESULTS:

Eighty-six assessment questionnaires were completed. Maximum morbidity was reported immediately following diagnosis and in the 2-3 weeks following bone marrow transplantation. The greatest morbidity was observed in the pain, self-care, mobility, and emotion domains.

CONCLUSIONS:

In addition to facing a high risk of mortality, young children being treated for advanced neuroblastoma also experience considerable morbidity.

PMID:
15390299
DOI:
10.1002/pbc.20133
[Indexed for MEDLINE]

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