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Mov Disord. 2004 Dec;19(12):1503-5.

Nurr1 mutational screen in Parkinson's disease.

Author information

1
Division of Research, SingHealth, Singapore. gnrtek@sgh.com.sg

Abstract

We performed sequence analysis of all the exons and exon-intron boundaries in familial and young-onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 C-->T variant among Malay and Indian PD and healthy controls, suggesting that this variant, which was previously described only in 1 Chinese patient, was not a silent mutation but a common polymorphic variant in some ethnic races.

PMID:
15390059
DOI:
10.1002/mds.20246
[Indexed for MEDLINE]
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