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Biol Cell. 2004 Aug;96(6):407-11.

Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2.

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Department of Biochemistry and Biotechnology, Institute of Biochemistry, Martin-Luther-University, Kurt-Mothes-Str. 3, 06120 Halle (Saale), Germany.


Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.

[Indexed for MEDLINE]

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