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J Pediatr. 1992 Mar;120(3):479-83.

Pharmacokinetics of lorazepam in critically ill neonates with seizures.

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1
Department of Pediatrics, Lutheran General Children's Medical Center, Park Ridge, Illinois.

Abstract

Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0.05 mg/kg or 0.1 mg/kg. All seizure activity ceased, with no adverse effects. Pharmacokinetic data revealed a decreased volume of distribution and clearance, and a prolonged half-life in comparison with data from older children and adults. These findings are consistent with physiologic differences in the neonate.

PMID:
1538303
[Indexed for MEDLINE]

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