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Int J Biochem Cell Biol. 2005 Jan;37(1):27-32.

Autoimmune heart failure: new understandings of pathogenesis.

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1
Medicine A, Department of Internal Medicine, University Hospital, Petersgraben 4, CH-4031 Basle, Switzerland. ueriksson@uhbs.ch

Abstract

Besides genetic susceptibility and infections with cardiotropic viruses, autoimmune responses against heart tissue play a major role in the pathogenesis of dilated cardiomyopathy, the most common cause of heart failure in young patients. Recent findings suggest that the combination of tissue damage resulting in release of self-antigens, together with non-specific activation of the innate immune system triggers various responses that are crucial for the development of heart-specific autoimmunity. Understanding these mechanisms is critical for the design and development of novel treatment strategies against devastating heart diseases in the future.

PMID:
15381145
DOI:
10.1016/j.biocel.2004.06.014
[Indexed for MEDLINE]
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