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Microbes Infect. 2004 Oct;6(12):1102-9.

Requirements for Th1-dependent immunity against infection with Leishmania major.

Author information

1
Department of Dermatology, Johannes Gutenberg-University, Langenbeckstrasse 1, D-55101 Mainz, Germany. vonstebu@mail.uni-mainz.de

Abstract

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

PMID:
15380780
DOI:
10.1016/j.micinf.2004.05.024
[Indexed for MEDLINE]

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