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Cancer Cell. 2004 Sep;6(3):209-14.

c-Src and cooperating partners in human cancer.

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Cancer Center and Department of Microbiology, University of Virginia Health System, P.O. Box 800734, Charlottesville, VA 22908, USA.


The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits elevated protein levels and activity in numerous types of human cancers. Furthermore, it has been found to be a critical component of multiple signaling pathways that regulate proliferation, survival, metastasis, and angiogenesis. Because of its important role in these oncogenic processes, it represents a therapeutic target ripe for exploitation.

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