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Leuk Res. 2004 Nov;28(11):1217-20.

Interferon alpha (IFN) treatment of bone marrow stroma inhibits haematopoesis.

Author information

1
Department of Medicine IV (Haematology and Oncology), Martin-Luther-University, Halle-Wittenberg, Ernst-Grube-Street 40, Halle (Saale) D-06120, Germany. christoph.kasper@web.de

Abstract

Prolonged pre-transplant IFN administration in patients with chronic myeloid leukaemia has been associated with an increased risk of fatal transplant-related complications and an inferior outcome after allogeneic bone marrow transplantation. Using a two-stage long-term bone marrow culture as an in vitro model we were able to show a negative effect of higher doses of IFN pre-treatment of bone marrow stroma on haematopoesis. This correlated with a decline in the number of monocytes-macrophages. While monocytes-macrophages itself produce cytokines, a vicious circle may lead to an ineffective function of the microenvironment resulting in ineffective haematopoieses and increased transplant-related complications.

PMID:
15380348
DOI:
10.1016/j.leukres.2004.03.012
[Indexed for MEDLINE]

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