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Bioorg Med Chem Lett. 2004 Oct 18;14(20):5199-203.

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands.

Author information

1
Graduate Group in Biophysics, University of California--San Francisco, San Francisco, CA 94143-2280, USA.

Abstract

A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) mediated transcription in vitro, dissociating transactivation, AP-1 repression, and NF-kappaB repression from each other.

PMID:
15380227
DOI:
10.1016/j.bmcl.2004.07.052
[Indexed for MEDLINE]

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