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Bioorg Med Chem Lett. 2004 Oct 18;14(20):5151-5.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

Author information

1
Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. scott_edmondson@merck.com

Abstract

In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM). Optimization of 3 led to compound 37, which is among the most potent and selective DPP-IV inhibitors discovered to date.

PMID:
15380217
DOI:
10.1016/j.bmcl.2004.07.056
[Indexed for MEDLINE]
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