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Mini Rev Med Chem. 2004 Sep;4(7):793-804.

Homology-based modelling of targets for rational drug design.

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  • 1Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, N-7489 Trondheim.

Abstract

The current status in rational drug design using homology-based models is discussed, with focus on template selection, model building, model verification and strategies for drug design based on model structures. A novel approach for identification of unique binding site features from homology-based models, Protein Alpha Shape Similarity Analysis (PASSA) is described.

PMID:
15379646
[PubMed - indexed for MEDLINE]
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