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Immunohematology. 1998;14(4):138-40.

Detection of anti-D following antepartum injections of Rh immune globulin.

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Department of Pathology, The Ohio State University, 125 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA.


Antepartum prophylaxis using Rh immune globulin (RhIG) at 28 weeks of gestation is routine in unsensitized Rh-negative women. As various sources state that anti-D may be detected up to 6 months after administration, we reviewed the medical and laboratory records of all Rh-negative women who delivered at our institution during 1995. For 385 evaluable women, only 137 (35.6%) had anti-D demonstrable in their sera at delivery; 97.8 percent of these delivered within 75 days after administration of RhIG. Of 248 women (64.4%) who delivered in < 76 days after administration of RhIG, 134 (54%) had demonstrable anti-D. For 123 women who delivered between 76 to 95 days after RhIG, only 3 (2.4%) had demonstrable anti-D. Of 14 women who delivered more than 96 days after RhIG, none had anti- D at delivery. These data show that the 300-microg dose used in the United States may not be adequate for antepartum protection and that the detection of anti-D more than 100 days after the administration of RhIG should be viewed with suspicion.

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